I don't know why, but this is the only acne cream that my skin responds well to. Actually, my skin responds amazingly to this! I've used this cream for a couple years, and whenever I run out, my skin gets a little crazy. My skin is dry with the occasional cystic breakout, for reference. I'll try to put off going back to the doctor to get more, but I always end up having to go back to renew my prescription for this. It's just great and no other acne cream compares. Something about this formula is oddly moisturizing, which works very nicely in combating the severe dryness that can occur from the benzoyl peroxide that this treatment also contains. The combination of benzoyl peroxide and clindamycin in this acne cream is almost like magic! I recently tried a tretinoin/clindamycin acne topical treatment that was disastrous, and left my skin in need of serious repair. Also, whenever I try just plain benzoyl peroxide acne treatments from the drugstore they somehow manage to dry out my skin so badly, while hardly doing anything for my acne. It's not really worth it for the dryness that occurs with drugstore treatments. Like I said, this treatment is oddly moisturizing which is perfect in such an effective acne treatment. Bottom line, this stuff works. Nothing works for my skin other than this cream (stomps cystic acne, and stops any other form of acne in its tracks). I also had a weird bumpy acne-like rash of skin colored tiny bumps about a year ago on my forehead which nothing cleared up, but this stuff did! This cream solves all my skin issues. I couldn't recommend this more!