OK, this product does work to help rebuild the collagen and fight wrinkles. But it's very hard to get it right,...at least for me. My skin is extremely reactive to too much or too frequent of applications. I can handle every 2-3 days. My skin has never developed a tolerance. Additionally (yeah, there's more), it has to be applied to TOTALLY dry skin. Meaning that I have to wait at least 20 minutes after washing my face or applying another product (I only apply toner and serums -- for me, TNS) beforehand. THEN, I have to wait about 30-45 minutes to apply moisturizer.
ALSO be warned DO NOT wax while using this or for a long while after. I made the mistake of a brow wax (reasoning I don't use it near my eyes, right?) and learned after chunks of skins were torn off that the product "travels." So I now have my brows threaded (which is amazing by the way!). Also, you must avoid the sun. Trust me on this one too. Sunscreen is a must; even on the drive to the market, etc. SPF all the time.
When I don't honor the foregoing musts, I pay the price with red, inflamed, peeling skin that kinda' defeats the purpose!
Clearly, I still use this stuff, and it is very expensive and requires a Rx. (As for the price tag - a little goes a looong way - at least a year for me). But Renova is not without it's drawbacks. Good luck!