I'm about to turn 30 and have been using good, old-fashioned Retin-A for almost 6 years. It is the only constant in my skin care routine! I really do recommend it to everyone I know as long as their skin isn't too sensitive. It is truly an incredible product. I have struggled with Acne on and off since high school and it's the only thing that really keeps my skin in check. It's also been a big help in reversing a bit of the damage I did to my skin for so many years drying it out with teenage acne skin care crap and just being an irresponsible kid going out into the sun and baking instead of protecting my skin! It reduced the appearance of my pores, has helped greatly with my skin texture and tone, and have barely any fine lines. After using it for this long you really do see how well it treats and also prevents. All of that being said, you have to really get to know your face and your skin if you're going to use this. It can be drying, irritating, make you red, make you peel, and make you REALLY sensitive to the sun. It's just one of those products you have to get used to. I have royally screwed myself by going into the sun without proper protection. If you have incredibly sensitive skin, I just don't know if i'd use the prescription version. I know there are some more gentle products with retinol in them that are designed specifically for sensitive skin, so if that is your issue try those. Okay, now for my crazy theory... I first purchased Retin A at a drugstore in China almost 7 years ago and I fell in love. When I ran out I had my doctor write a rx and it just... wasn't the same. On a later trip to Asia I grabbed more and again, it worked like a dream. Maybe it was my skin. Maybe it was the timing or something else I was using, but the American version just doesn't seem to be as... good. I have since started stock piling it and making my friends pick me up a few tubes anytime one of them travels to a place that sells it OTC. Maybe i'm nuts, but I swear there is a difference between the Asian and South American VS the American version. has anyone else noticed a difference between the two?